Tuesday, March 6, 2012

This Day in History: Mar 6, 1899: Bayer patents aspirin

On this day in 1899, the Imperial Patent Office in Berlin registers Aspirin, the brand name for acetylsalicylic acid, on behalf of the German pharmaceutical company Friedrich Bayer & Co.
Now the most common drug in household medicine cabinets, acetylsalicylic acid was originally made from a chemical found in the bark of willow trees. In its primitive form, the active ingredient, salicin, was used for centuries in folk medicine, beginning in ancient Greece when Hippocrates used it to relieve pain and fever. Known to doctors since the mid-19thcentury, it was used sparingly due to its unpleasant taste and tendency to damage the stomach.

 
In 1897, Bayer employee Felix Hoffman found a way to create a stable form of the drug that was easier and more pleasant to take. (Some evidence shows that Hoffman's work was really done by a Jewish chemist, Arthur Eichengrun, whose contributions were covered up during the Nazi era.) After obtaining the patent rights, Bayer began distributing aspirin in powder form to physicians to give to their patients one gram at a time. The brand name came from "a" for acetyl, "spir" from the spirea plant (a source of salicin) and the suffix "in," commonly used for medications. It quickly became the number-one drug worldwide.

Aspirin was made available in tablet form and without a prescription in 1915. Two years later, when Bayer's patent expired during the First World War, the company lost the trademark rights to aspirin in various countries. After the United States entered the war against Germany in April 1917, the Alien Property Custodian, a government agency that administers foreign property, seized Bayer's U.S. assets. Two years later, the Bayer company name and trademarks for the United States and Canada were auctioned off and purchased by Sterling Products Company, later Sterling Winthrop, for $5.3 million.

Bayer became part of IG Farben, the conglomerate of German chemical industries that formed the financial heart of the Nazi regime. After World War II, the Allies split apart IG Farben, and Bayer again emerged as an individual company. Its purchase of Miles Laboratories in 1978 gave it a product line including Alka-Seltzer and Flintstones and One-A-Day Vitamins. In 1994, Bayer bought Sterling Winthrop's over-the-counter business, gaining back rights to the Bayer name and logo and allowing the company once again to profit from American sales of its most famous product. 

In South Africa: Armistice is concluded during the First Anglo-Boer War

Date: 6 March, 1881

Paving the way for the end of  Anglo-Boer War 1 (Transvaal War of Independence or First Transvaal War), a provisional armistice was agreed upon by General Evelyn Wood of the British forces and Republican General J.P. Joubert. This led to the commencement of peace negotiations, which was concluded on 23 March 1881. The final end of the war was reached with the signing of the Convention of Pretoria on 3 August 1881, recognising limited independence of the Transvaal Republic. The Volksraad accepted the provisions of the Convention with reluctance, as it differed considerably from those agreed upon in March.

The southern part of the African continent was dominated in the 19th century by a set of epic struggles to create within it a single unified state. British aggression into southern Africa was fuelled by three prime factors: first, the desire to control the trade routes to India that passed around the Cape; second, the discovery in 1868 of huge mineral deposits of diamonds around Kimberley on the joint borders of the South African Republic (called the Transvaal by the British), Orange Free State and the Cape Colony, and thereafter in 1886 in the Transvaal of a major gold find, all of which offered enormous wealth and power; and thirdly the race against other European colonial powers, as part of a general colonial expansion in Africa. Other potential colonisers included Portugal, who already controlled West (modern day Angola) and East Africa (modern day Mozambique), Germany (modern day Namibia), and further north, Belgium (modern day Democratic Republic of the Congo) and France (West and Equatorial Africa, and Madagascar).

The British attempts in 1880 to annexe the Transvaal, and in 1899 both the Transvaal and the Orange Free State (leading to the Second Boer War), were their biggest incursions into southern Africa, but there were others. In 1868, the British annexed Basutoland in the Drakensberg Mountains (modern Lesotho, surrounded by the Orange Free State and Natal) following an appeal from Moshesh, the leader of a mixed group of African refugees from the Zulu wars, who sought British protection against both the Boers and the Zulus. In the 1880s, Bechuanaland (modern Botswana, located north of the Orange River) became an object of dispute between the Germans to the west, the Boers to the east, and the British in the Cape Colony to the south. Although Bechuanaland had almost no economic value, the "Missionaries Road" passed through it toward territory farther north. After the Germans annexed Damaraland and Namaqualand (modern Namibia) in 1884, the British annexed Bechuanaland in 1885.
Britain Battle of Blaauwberg had acquired the Cape of Good Hope in South Africa from the Dutch in 1815 during the Napoleonic Wars. Certain groups of Dutch-speaking settler farmers ("Boers") resented British rule, even though British control brought some economic benefits. There were successive waves of migrations of Boer farmers (known as Trekboers which literally means "moving farmers"), first east along the coast away from the Cape toward Natal, and thereafter north toward the interior, eventually establishing the republics that came to be known as the Orange Free State and the Transvaal (literally "across/beyond the Vaal River," a tributary of the Orange River).

The British did not try to stop Trekboers from moving away from the Cape. The Trekboers served as pioneers, opening up the interior for those who followed, and the British gradually extended their control away from the Cape along the coast toward the east, eventually annexing Natal in 1845. Indeed, the British subsequently ratified the two new Republics in a pair of treaties: the Sand River Convention of 1852 which recognised the independence of the Transvaal Republic, and the Bloemfontein Convention of 1854 which recognised the independence of the Orange Free State. However, British colonial expansion was, from the 1830s, marked by skirmishes and wars against both Boers and native African tribes for most of the remainder of the century.

The discovery of diamonds in 1867 near the Vaal River, some 550 miles (890 km) northeast of Cape Town, ended the isolation of the Boers in the interior and changed South African history. The discovery triggered a "diamond rush" that attracted people from all over the world, turning Kimberley into a town of 50,000 within five years and drawing the attention of British imperial interests. In the 1870s, the British annexed West Griqualand, site of the Kimberley diamond discoveries.
In 1875 Prime Minister Benjamin Disraeli's Colonial Secretary, Lord Carnarvon, in an attempt to extend British influence, approached the Orange Free State and the Transvaal Republic and tried to organise a federation of the British and Boer territories to be modelled after the 1867 federation of French and English provinces of Canada, however the Boer leaders turned him down. The successive British annexations, and in particular the annexation of West Griqualand, caused a climate of simmering unease for the Boer republics.

Outbreak of War

With the defeat of the Zulus, and the Pedi, the Transvaal Boers were able to give voice to the growing resentment against the 1877 British annexation of the Transvaal and complained that it had been a violation of the Sand River Convention of 1852, and the Bloemfontein Convention of 1854.
Major-General Sir George Pomeroy Colley, after returning briefly to India, finally took over as Governor of Natal, Transvaal, High Commissioner of SE Africa and Military Commander in July 1880. Multiple commitments prevented Colley from visiting the Transvaal where he knew many of the senior Boers. Instead he relied on reports from the Administrator, Sir Owen Lanyon, who had no understanding of the Boer mood or capability. Belatedly Lanyon asked for troop reinforcements in December 1880 but was overtaken by events.
The Boers on 16 December 1880 revolted and took action at Bronkhorstspruit against a British column of the 94th Foot, who were returning to reinforce Pretoria.

1880–81 War

After Transvaal formally declared independence from the United Kingdom, the war began on 16 December 1880 with shots fired by Transvaal Boers at Potchefstroom. This led to the action at Bronkhorstspruit on 20 December 1880, where the Boers ambushed and destroyed a British Army convoy. From 22 December 1880 to 6 January 1881, British army garrisons all over the Transvaal became besieged.

Although generally called a war, the actual engagements were of a relatively minor nature considering the few men involved on both sides and the short duration of the combat, lasting some ten weeks of sporadic action.
The fiercely independent Boers had no regular army; when danger threatened, all the men in a district would form a militia organised into military units called commandos and would elect officers. Commandos being civilian militia, each man wore what he wished, usually everyday dark-grey, neutral-coloured, or earthtone khaki farming clothes such as a jacket, trousers and slouch hat. Each man brought his own weapon, usually a hunting rifle, and his own horses. The average Boer citizens who made up their commandos were farmers who had spent almost all their working life in the saddle, and, because they had to depend on both their horse and their rifle for almost all of their meat, they were skilled hunters and expert marksmen. Most of the Boers had single-shot breech loading rifle such as the Westley Richards, the Martini-Henry, or the Remington Rolling Block. Only a few had repeaters like the Winchester or the Swiss Vetterli. As hunters they had learned to fire from cover, from a prone position and to make the first shot count, knowing that if they missed the game would be long gone. At community gatherings, they often held target shooting competitions using targets such as hens' eggs perched on posts over 100 yards away. The Boer commandos made for expert light cavalry, able to use every scrap of cover from which they could pour accurate and destructive fire at the British with their breech loading rifles.
 
The British infantry uniforms at that date were red jackets, black trousers with red piping to the side, white pith helmets and pipe clayed equipment, a stark contrast to the African landscape. The Highlanders wore the kilt. The standard infantry weapon was the Martini Henry single-shot breech loading rifle with a long sword bayonet. Gunners of the Royal Artillery wore blue jackets. This enabled the Boer marksmen easily to snipe at red-clad British troops from a distance. The Boers carried no bayonets leaving them at a substantial disadvantage in close combat, which they avoided as far as possible. Drawing on years of experience of fighting frontier skirmishes with numerous and indigenous African tribes, they relied more on mobility, stealth, marksmanship and initiative while the British emphasised the traditional military values of command, discipline, formation and synchronised firepower. The average British soldier was not trained to be a marksman and got little target practice. What shooting training British soldiers had was mainly as a unit firing in volleys on command.

At the first battle at Bronkhorstspruit, Lieutenant-Colonel Anstruther and 120 men of the 94th Foot (Connaught Rangers) were dead or wounded by Boer fire within minutes of the first shots. Boer losses totalled two killed and five wounded. This mainly Irish regiment was marching westward toward Pretoria, led by Lieutenant-Colonel Anstruther, when halted by a Boer commando group. Its leader, Piet Joubert, ordered Anstruther and the column to turn back, stating that the territory was now again a Boer Republic and therefore any further advance by the British would be deemed an act of war. Anstruther refused and ordered that ammunition be distributed. The Boers opened fire and the ambushed British troops were annihilated. With the majority of his troops dead or wounded, the dying Anstruther ordered surrender.

The Boer uprising caught by surprise the six small British forts scattered around Transvaal, housing some 2,000 troops between them, including irregulars with as few as fifty men at Lydenburg in the east where Anstruther had just left. Being isolated, and with so few troops, all the forts could do was prepare for sieges, and wait to be relieved. The other five forts, with a minimum of fifty miles between any two, were at Wakkerstroom and Standerton in the south, Marabastadt in the north and Potchefstroom and Rustenburg in the west.

The three main engagements of the war were all within about sixteen miles of each other, centred on the Battles of Laing’s Nek (28 January 1981), Ingogo River (8/2/81) and the rout at Majuba Hill (27 February 1981). These battles were the outcome of Major-General Sir George Pomeroy Colley’s attempts to relieve the besieged forts. Although Colley had requested reinforcements these would not reach him until mid-February. He was, however, convinced that the garrisons would not survive until then. Consequently, at Newcastle, near the Transvaal border he mustered a relief column (the Natal Field Force) of available men although this amounted to only 1,200 men. Colley’s force was further weakened in that few were mounted, a serious disadvantage in the terrain and type of warfare. Most Boers were mounted and good riders. Nonetheless, Colley’s force set out on 24 January 1881 northward for Laing’s Nek on route to relieve Wakkerstroom and Standerton, the nearest forts.
At the Battle of Laing's Nek on 28 January 1881, the Natal Field Force under Major-General Sir George Pomeroy Colley attempted with cavalry and infantry attacks to break through the Boer positions on the Drakensberg mountain range to relieve their garrisons. The British were repulsed with heavy losses by the Boers under the command of Piet Joubert. Of the 480 British troops who made the charges, 150 never returned. Furthermore, sharpshooting Boers had killed or wounded many senior officers.

Further actions included the Battle of Schuinshoogte (also known as Ingogo) on 8 February 1881, where another British force barely escaped destruction. Major-General Sir George Pomeroy Colley had sought refuge with the Natal Field Force at Mount Prospect, three miles to the south to await reinforcements. However, Colley was soon back into action. On 7 February a mail escort on its way to Newcastle had been attacked by the Boers and forced back to Mount Prospect. The next day Colley, determined to keep his supplies and communication route open, escorted the mail wagon personally and this time with a larger escort. The Boer attacked the convoy at the Ingogo River crossing, but with a stronger force of some 300 men. The firepower was evenly matched and the fight continued for several hours, but the Boer marksmen dominated the action until darkness and a storm permitted Colley and the remainder of his troops to retreat back to Mount Prospect. In this engagement the British lost 139 officers and men, half the original force that had set out to escort the mail convoy.
On 14 February hostilities were suspended, awaiting the outcome of peace negotiations initiated by an offer from Kruger. During this time Colley’s promised reinforcements arrived with more to follow. The British government in the meantime had offered a Royal Commission investigation and possible troop withdrawal, and their attitude toward the Boers was conciliatory. Colley was critical of this stance and, whilst waiting for Kruger’s final agreement, decided to attack again with a view to enabling the British government to negotiate from a position of strength. Unfortunately this resulted in the disaster of the Battle of Majuba Hill on 27 February 1881, the greatest humiliation for the British.
On 26 February 1881, Colley led a night march of some 360 men to the top of Majuba Hill that overlooked the main Boer position. Early the next morning the Boers saw Colley occupying the summit, and started to ascend the hill. The Boers, shooting accurately and using all available natural cover, advanced toward the trapped British position. Several Boer groups stormed the hill and drove off the British at great cost to the British, including the loss of Major-General Colley. Many of the British were killed or wounded, some falling to their deaths down the mountain. This had such an impact that during the Second Boer War, one of the British slogans was "Remember Majuba." The Boers suffered only one killed and five wounded.

Hostilities continued until 6 March 1881, when a truce was declared, ironically on the same terms that Colley had disparaged. The Transvaal forts had endured, contrary to Colley’s forecast, with the sieges being generally uneventful, the Boers content to wait for hunger and sickness to strike. The forts had suffered only light casualties as an outcome of sporadic engagements, except at Potchefstroom, where twenty-four were killed, and seventeen at Pretoria, in each case resulting from occasional raids on Boer positions.

Although the Boers exploited their advantages to the full, their unconventional tactics, marksman skills and mobility do not fully explain the heavy losses of the British. Like the Boers, British soldiers were equipped with breech-loading rifles (the Martini-Henry) but they were (unlike the Boers) professionals and the British Army had previously fought campaigns in difficult terrains and against elusive enemy such as the tribesmen of the Northern Territories in modern day Afghanistan. Historians lay much of the blame at the feet of the British command and Major-General Sir George Pomeroy Colley, in particular, but poor intelligence and bad communications also contributed to British losses. At Laing’s Nek it seems that Colley not only underestimated the Boer capabilities, but had been misinformed of, and was surprised by, the strength of the Boers forces. The confrontation at Ingogo Nek was perhaps rash, given that reserves were being sent, and Colley had by then experienced the Boer strength and capabilities. Indeed, strategists have speculated as to whether the convoy should have proceeded at all when it was known to be vulnerable to attack, and whether it was necessary for Colley himself to take command of the British guard. Colley's decision to initiate the attack at Majuba Hill when truce discussions were already underway appears to have been foolhardy particularly as there was limited strategic value, as the Boer positions were out of rifle range from the summit. Once the Battle of Majuba Hill had begun, Colley’s command and understanding of the dire situation seemed to deteriorate as the day went on, as he sent unclear signals to the British forces at Mount Prospect by heliograph, first requesting reinforcements and the next stating that the Boers were retreating. The poor leadership, intelligence and communications resulted in the deaths of many British soldiers.


Sources:
  • Potgieter, D.J. et al. (eds)(1970). Standard Encyclopaedia of Southern Africa, Cape Town: NASOU, v. 1, p. 383 & v. 10, p. 611."/>
  • Duxbury, Geo. R. David and Goliath: The First War of Independence, 1880–1881 (Johannesburg: SA National Museum of Military History, 1981).
  • Gross, David (ed.) We Won’t Pay!: A Tax Resistance Reader ISBN 1434898253 pp. 169–174


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